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  • Title: A case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndrome.
    Author: Noorlander I, Elte JW, Manintveld OC, Tournoy KG, Praet MM, van Meerbeeck JP, Aerts JG.
    Journal: Lung Cancer; 2006 Feb; 51(2):251-5. PubMed ID: 16352372.
    Abstract:
    Secretion of ectopic adrenocorticotropic hormone (ACTH) with consequently Cushing's syndrome is a rare paraneoplastic phenomenon. It has been described in a variety of malignancies, like bronchial carcinoids, small-cell lung carcinoma, thymoma, pancreatic carcinoma and other. In many cases of suspected ectopic ACTH secretion, it is difficult to histologically or cytochemically confirm the diagnosis. We present a 63-year-old woman with a recurrent poorly differentiated squamous cell lung carcinoma with clinical and biochemical features consistent with ectopic Cushing's syndrome. Immunocytochemical staining confirmed the secretion of ACTH by tumour cells.
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