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  • Title: Cyclooxygenase-1 and cyclooxygenase-2 inhibition of novel 1,2-disubstituted imidazoles.
    Author: Handler N, Jaeger W, Kuen-Krismer B, Erker T.
    Journal: Arch Pharm (Weinheim); 2005 Dec; 338(12):602-4. PubMed ID: 16353278.
    Abstract:
    Novel 1,2-disubstituted imidazoles were synthesized and tested for COX-1 and COX-2 inhibition. A substituted phenyl cycle in position 1 and an alicyclic tertiary alcohol in position 2 gave COX-1-selective compounds with potency and selectivity depending on the different substituents.
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