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  • Title: Apoptotic potential of sesquiterpene lactone ergolide through the inhibition of NF-kappaB signaling pathway.
    Author: Song YJ, Lee DY, Kim SN, Lee KR, Lee HW, Han JW, Kang DW, Lee HY, Kim YK.
    Journal: J Pharm Pharmacol; 2005 Dec; 57(12):1591-7. PubMed ID: 16354403.
    Abstract:
    Treatment with ergolide, a sesquiterpene lactone from Inula britannica var chinensis, caused the induction of apoptosis in Jurkat T cells, which was confirmed by DNA fragmentation, caspase-3 activation and cleavage of poly(ADP-ribose) polymerase in response to ergolide. Furthermore, mitochondrial dysfunction appeared to be associated with ergolide-induced apoptosis, because Bax translocation and cytochrome c release were stimulated by ergolide. In parallel, the nuclear factor-kappaB (NF-kappaB) signaling pathway was significantly inhibited by ergolide, which was accompanied by down-regulation of cell survival molecules, such as X-chromosome-linked inhibitor of apoptosis and Bcl-2. In addition, the JNK signaling pathway was involved in ergolide-induced apoptosis. Collectively, our results identified a new mechanism for the anti-cancer property of ergolide, attributable to the induction of apoptosis through down-regulation of cell survival signal molecules resulting from inhibition of the NF-kappaB signaling pathway.
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