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  • Title: Determination of theophylline concentration in serum by chemiluminescent immunoassay.
    Author: Zhou MX, Guan CY, Chen G, Xie XY, Wu SH.
    Journal: J Zhejiang Univ Sci B; 2005 Dec; 6(12):1148-52. PubMed ID: 16358370.
    Abstract:
    OBJECTIVE: This study aimed to establish chemiluminescent immunoassay (CLIA) for quantitative determination of theophylline levels in human serum. METHODS: To measure the concentration of theophylline (n=122) and evaluate the assay. RESULTS: The linear range of the CLIA method was 0.51-40 mg/L (Y=1.02X+0.44, r=0.995). The intra and inter CV (coefficient variance) of CLIA were 3.20% and 3.57%, respectively. The average recovery rate was 102.3%. This method was free from interference by brilirubin (<200 micromol/L), hemoglobin (<10 g/L), and triglycerides (<15 mmol/L). CONCLUSION: This method is simple, convenient and precise for clinical pharmacokinetics study of theophylline.
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