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  • Title: The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy.
    Author: Danko I, Chapman V, Wolff JA.
    Journal: Pediatr Res; 1992 Jul; 32(1):128-31. PubMed ID: 1635838.
    Abstract:
    The mdx mouse has been used for the development of cellular and gene therapies for Duchenne muscular dystrophy. The relatively frequent occurrence of dystrophin-positive muscle cells called revertants has hampered these efforts by interfering with data interpretation. The mdx4cv and mdx5cv dystrophin mouse mutants have approximately 10-fold fewer revertants than the mdx mutant at both 2 and 6 mo. The mdx3cv dystrophin mouse mutant may be a useful model for some types of human dystrophin deficiencies in which the levels of dystrophin are low but not completely absent.
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