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  • Title: [Determination of the conversion of air oxidation of penicillin derivatives by high performance liquid chromatography].
    Author: Hu QY, Zhao JQ, Zhu LD, Li MQ, Li GH, Wang Y, Ge FY.
    Journal: Se Pu; 2002 Sep; 20(5):459-61. PubMed ID: 16358703.
    Abstract:
    In air oxidation of penicillin G p-methoxybenzyl ester (PGPMB) to its sulfoxides (PGPMBO), sol-gel technique was employed to encapsulate the catalyst Co (acac)3, by which the reaction was run under heterogeneous conditions. A reversed-phase high performance liquid chromatographic method was established for the determination of the conversion of this reaction. The analysis of PGPMBO was carried out on a C18 column (4.6 mm i.d. x 150 mm, 10 microm) with the mobile phase of methanol-water (85:15, V/V), at a flow rate of 1 mL min(-1) and with detection wavelength of 270 nm. The linearity of the calibration curve of PGPMBO was obtained over the range of 0.05 g x L(-1) - 0.40 g x L(-1) with a relative coefficient of 0.999 2. The highest conversion was 98.8%. The method can be applied to determine this conversion promptly in the reaction system.
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