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  • Title: [Lanthanides induce neurotransmitter release from the vesicular pool in rat brain synaptosomes].
    Author: Lopatina LP, Vasim TV, Fedorovich SV, Konev SV.
    Journal: Biofizika; 2005; 50(6):1120-4. PubMed ID: 16358793.
    Abstract:
    The influence of lanthanoids on exocytosis was investigated. It was shown that gadolinium increases the spontaneous release of the glutamate nonmetabolizing analogue [3H]D-aspartate. It was established using the fluorescent dye acridine orange that gadolinium and lanthanum induce exocytosis. The effect was dose-dependent and was maximum at 300 microM Gd3+. The exocytosis induced by gadolinium was calcium-independent. It is suggested that lanthanides induce a vesicular release of neurotransmitters by the mechanisms common for all polyvalent cations.
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