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  • Title: Synthesis and antihyperglycemic evaluation of various protoberberine derivatives.
    Author: Bian X, He L, Yang G.
    Journal: Bioorg Med Chem Lett; 2006 Mar 01; 16(5):1380-3. PubMed ID: 16359864.
    Abstract:
    Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of beta-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.
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