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  • Title: Corpus callosum functioning in patients with normal pressure hydrocephalus before and after surgery.
    Author: Mataró M, Poca MA, Matarín M, Sahuquillo J, Sebastián N, Junqué C.
    Journal: J Neurol; 2006 May; 253(5):625-30. PubMed ID: 16362531.
    Abstract:
    OBJECTIVES: Our aim was to evaluate corpus callosum functioning in a group of patients with normal pressure hydrocephalus (NPH) before and after shunting. METHODS: Left ear-extinction under a dichotic listening task was evaluated in twenty-three patients with NPH, 30 patients with Alzheimer's disease and 30 aged controls. RESULTS: Patients with NPH had higher levels of left ear extinction than the control and Alzheimer's groups. Sixty-one percent of NPH patients exhibited left ear suppression, compared with 13% of Alzheimer's patients and 17% of controls. Following surgery, NPH patients showed a significant change in the degree of asymmetry in the dichotic listening task. CONCLUSIONS: Hydrocephalus was associated with left-ear extinction,which diminished after surgery. Our results may indicate reversible functional damage in the corpus callosum.
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