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  • Title: Interaction of kinesin motors, microtubules, and MAPs.
    Author: Marx A, Müller J, Mandelkow EM, Hoenger A, Mandelkow E.
    Journal: J Muscle Res Cell Motil; 2006; 27(2):125-37. PubMed ID: 16362723.
    Abstract:
    Kinesins are a family of microtubule-dependent motor proteins that carry cargoes such as vesicles, organelles, or protein complexes along microtubules. Here we summarize structural studies of the "conventional" motor protein kinesin-1 and its interactions with microtubules, as determined by X-ray crystallography and cryo-electron microscopy. In particular, we consider the docking between the kinesin motor domain and tubulin subunits and summarize the evidence that kinesin binds mainly to beta tubulin with the switch-2 helix close to the intradimer interface between alpha and beta tubulin.
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