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  • Title: The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection.
    Author: Nattermann J, Ahlenstiel G, Berg T, Feldmann G, Nischalke HD, Müller T, Rockstroh J, Woitas R, Sauerbruch T, Spengler U.
    Journal: J Viral Hepat; 2006 Jan; 13(1):42-6. PubMed ID: 16364081.
    Abstract:
    The C-type lectin DC-SIGNR has been shown to bind hepatitis C virus (HCV). Here, we analysed the tandem-repeat polymorphism of the DC-SIGNR gene with respect to intraindividual HCV replication. In a cross-sectional comparison HCV-infected patients (n = 430) and healthy subjects (n = 100) were genotyped for the DC-SIGNR polymorphism using PCR. The distribution of DC-SIGNR alleles did not differ significantly between the two groups. However, HCV-infected patients with 5-, 6-, and 7-repeat alleles had higher HCV-RNA levels when compared with carriers of 4- and 9-repeat alleles (P < 0.05). Thus, the DC-SIGNR polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.
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