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  • Title: Feedback regulation of 25-hydroxycholecalciferol metabolism by vitamin D3.
    Author: Evans IM, Colston KW, Galante L, MacIntyre I.
    Journal: Clin Sci Mol Med; 1975 Mar; 48(3):227-30. PubMed ID: 163720.
    Abstract:
    1. In vitamin D-deficient chicks both vitamin D3 and 1alpha-hydroxycholecalciferol markedly decrease renal 1-hydroxylase activity and induce 24-hydroxylase activity. 2. Actinomycin D abolishes both effects. 3. These results are consistent with feedback regulation of vitamin D3 metabolism by a direct nuclear action of the vitamin or its metabolites on the kidney cells.
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