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  • Title: Dexamethasone reduces reintubation rate due to postextubation stridor in a high-risk paediatric population.
    Author: Lukkassen IM, Hassing MB, Markhorst DG.
    Journal: Acta Paediatr; 2006 Jan; 95(1):74-6. PubMed ID: 16373300.
    Abstract:
    OBJECTIVE: To study the effect of dexamethasone on postextubation stridor (PS) incidence and reintubation rate due to PS in a high-risk paediatric intensive care population. PATIENTS AND METHODS: All children aged between 4 wk and 6 y, who were intubated for at least 24 h and extubated between August 1999 and May 2002, were retrospectively included (n=60). Medical records of the included patients were studied; records of patients treated with dexamethasone prior to and following extubation (n=23) were compared with control patients who had not received prophylactic medication (n=37). RESULTS: Nine patients in the control group developed significant postextubation stridor, necessitating nebulized epinephrine or glucocorticosteroids. In six of these children, reintubation as a result of postextubation stridor was indicated. None of the patients treated with dexamethasone developed severe postextubation stridor or required reintubation. CONCLUSIONS: The risk of postextubation stridor is relatively high in the group of children aged between 4 wk and 6 y with intubation exceeding 24 h. We found dexamethasone to be effective in preventing reintubation due to postextubation stridor in this paediatric high-risk group.
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