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  • Title: Role of 1,4-benzothiazine derivatives in medicinal chemistry.
    Author: Fringuelli R, Milanese L, Schiaffella F.
    Journal: Mini Rev Med Chem; 2005 Dec; 5(12):1061-73. PubMed ID: 16375752.
    Abstract:
    1,4-Benzothiazine (1,4-BT) derivatives have been reported to exhibit a wide range of pharmacological properties including antifungal, immunostimulating, anti-aldoso-reductase, anti-rheumatic, anti-allergic, vasorelaxant, anti-arrhythmic, anti-hypertensive, neuroprotective and cytotoxic activities. These different effects indicate that 1,4-BT is a template potentially useful in medicinal chemistry research and therapeutic applications.
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