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  • Title: Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling.
    Author: Le Gal J, Michaud S, Gressier M, Coulais Y, Benoist E.
    Journal: Bioorg Med Chem; 2006 May 01; 14(9):2904-9. PubMed ID: 16376547.
    Abstract:
    A novel bifunctional chelating agent bearing an aromatic ring has been synthesised and characterised. This ligand formed well-defined oxorhenium complexes. The analogous 99mTcO-complex was obtained in an excellent yield with high radiochemical purity (>95%). The biodistribution of the 99mTc-complex after intravenous injection studied in normal rats showed that the activity was excreted mainly via renal-urinary pathway indicating its use for labelling peptides with 99mTc.
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