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  • Title: Novel and emerging therapies for asthma.
    Author: Leath TM, Singla M, Peters SP.
    Journal: Drug Discov Today; 2005 Dec; 10(23-24):1647-55. PubMed ID: 16376825.
    Abstract:
    At present, there are a wide variety of novel and emerging therapeutic approaches for the treatment of asthma. Here, we will summarize these state-of-the-art approaches, including specific and nonspecific mediator inhibition-- a quest that has been on going for more than 25 years-- together with cytokine modulation in asthma (primarily attempting to modulate the Th2-Th1 balance in asthma), targeting cell recruitment, angiogenesis, signal transduction and gene transduction pathways. Finally, we will discuss the recently approved anti-IgE therapy for the treatment of allergic asthma and immune modulation using CpG oligodeoxynucleotides.
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