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  • Title: ent-Kaurane Diterpenoids from Isodon albopilosus.
    Author: Huang SX, Zhao QS, Xu G, Xiao WL, Li RT, Hou AJ, Peng SL, Ding LS, Sun HD.
    Journal: J Nat Prod; 2005 Dec; 68(12):1758-62. PubMed ID: 16378369.
    Abstract:
    Nine new diterpenoids, albopilosins B-J (1-9), together with six known analogues, albopilosin A (10), macrocalyxin C (11), rabdokunmin C (12), excisanin (13), amethystonoic acid (14), and coetsanoic acid (15), were isolated from the aerial parts of Isodon albopilosus. The structures of 1-9 were established using spectroscopic methods including extensive 1D and 2D NMR analysis. The diterpenoids isolated were evaluated for their inhibitory activities against HepG2 (hepatoma) cells. Compounds 7 and 13 were the most active, with both having IC(50) values of <15 microM.
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