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  • Title: Relaxation and cyclic GMP levels in response to sildenafil in human pulmonary arteries from donors.
    Author: Mauricio MD, Segarra G, Medina P, Aldasoro M, Martínez-León JB, Vila JM.
    Journal: Eur J Pharmacol; 2006 Jan 20; 530(3):259-62. PubMed ID: 16380114.
    Abstract:
    We measured cyclic GMP formation and relaxation response to sildenafil given either alone or in combination with sodium nitroprusside (SNP) in pulmonary arteries obtained from 13 multi-organ donors. Sildenafil (10(-9)-10(-4) M) caused concentration-dependent relaxations and amplified the relaxation induced by SNP. Relaxation was unaffected by endothelium removal or by pre-treatment with the inhibitor of nitric oxide synthase L-NMMA (10(-4) M). SNP (10(-7) M) caused elevation of cyclic GMP levels that was potentiated by sildenafil (10(-6) M). Thus, the enhancement of SNP-induced relaxation by sildenafil is mainly due to an increase in cyclic GMP accumulation.
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