These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antibiotic principles from a Streptomyces species and their sub-acute toxicity studies on hepatic, renal and haemopoietic system of rats.
    Author: Chowdhury R, Musawwir F, Rashid RB, Mazid MA.
    Journal: Pak J Pharm Sci; 2005 Jul; 18(3):1-7. PubMed ID: 16380336.
    Abstract:
    Two promising antibiotics, JF-A and JF-B were isolated from the chloroform extract of a Banglaeshi Streptomyces strain. The mean zones of inhibition produced by the chloroform extract (400 microg/disc), JF-A (200 microg/disc) and JF-B (200 microg/disc) against 19 pathogenic bacteria were found to be 9-50, 12-38 and 10-41 mm while those produced by a standard antibiotic, kanamycin were 11-40 mm at 30 microg/disc. MICs of JF-A and JF-B were determined to be 64 microg/ml against Bacillus subtilis and 64 and 128 microg/ml against Shigella sonnei, respectively. The extract and the antibiotics were also tested for cytotoxicity against Artemia salina nauplii and LC50 values of 23.26, 18.05 and 32.27 microg/ml were obtained. 90% mortality of shrimp nauplii was observed at 69.18, 50.12 and 110.91 microg/ml, respectively. In a potato disc bioassay, the chloroform extract at 25 microg/disc demonstrated 37.39% inhibition of crown gall tumour induced by G -ve Agrobacterium tumefaciens B6 and the result was statistically significant (P < 0.05). The sub-acute toxicity studies on the JF-A and JF-B reflected innocuous nature of these antibiotics on hepatic, renal and haemopoietic system of rats at 1 mg/kg b.w. on daily administration for 21 consecutive days. This is also confirmed by detailed histopathological studies. No mortality was observed in experimental animals.
    [Abstract] [Full Text] [Related] [New Search]