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  • Title: Hyperthyroidism causes lipid peroxidation in kidney and testis tissues of rats: protective role of melatonin.
    Author: Mogulkoc R, Baltaci AK, Oztekin E, Aydin L, Tuncer I.
    Journal: Neuro Endocrinol Lett; 2005 Dec; 26(6):806-10. PubMed ID: 16380687.
    Abstract:
    OBJECTIVE: The present study aimed at determining how 3-week intraperitoneal melatonin administration affected oxidative stress caused by experimental hyperthyroidism. MATERIALS AND METHODS: The study was conducted on 30 male rats of Sprague-Dawley species. The experimental animals were divided to 3 groups (control, hyperthyroidism and hyperthyroidism+melatonin). The supplementation was continued for 3 weeks after which the animals were sacrificed and tissue malondyaldehyde (MDA) and glutathione (GSH) levels were determined. RESULTS: MDA levels in kidney and testis tissues in hyperthyroidism group were higher than those in control and hyperthyroidism+melatonin administered groups (p<0.001) and levels in hyperthyroidism+melatonin administered group were higher than those in the control group (p<0.001). The highest GSH levels were obtained in hyperthyroidism+melatonin-administered group (p<0.001) and GSH levels in hyperthyroidism group were higher than those in the control group (p<0.001). CONCLUSION: Results of the study demonstrate that hyperthyroidism induced by 3-week L-thyroxine administration increased oxidative stress in kidney and testis tissues and that although melatonin administration inhibited this stress to a certain extent, it could not bring the stress down to the level in controls.
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