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  • Title: [Influence of recombinant human growth hormone on the prognosis of patients with severe burns a prospective multi-center clinical trial].
    Author: Chen GX, Han CM.
    Journal: Zhonghua Shao Shang Za Zhi; 2005 Oct; 21(5):347-9. PubMed ID: 16383035.
    Abstract:
    OBJECTIVE: To investigate the influence of recombinant human growth hormone (rhGH) on the mortality of the patients with severe burns. METHODS: In a prospective multi-center randomized clinical trial, 207 adult patients with severe burns were enrolled in the study, and they were randomly divided into treatment (T, with subcutaneous injection of rhGH) and placebo control (C, with subcutaneous injection of same amount of isotonic saline) groups. The mortality, incidence of hyperglycemia and sepsis in the two groups were observed. RESULTS: The mortality rate in T group was 0.89% as compared with 5.26% in the C group (P >0.05). Hyperglycemia (blood glucose level over 10 mmol/L) was present in 36.61% of patients in T group but 18.95% in C group (P <0.01). There was no difference in the incidence of sepsis between the two groups (P > 0.05). CONCLUSION: The application of rhGH in appropriate dosage in adult patients with severe burns could be safe, but blood glucose level should be monitored during the administration.
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