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  • Title: Protein recognition via surface molecularly imprinted polymer nanowires.
    Author: Li Y, Yang HH, You QH, Zhuang ZX, Wang XR.
    Journal: Anal Chem; 2006 Jan 01; 78(1):317-20. PubMed ID: 16383343.
    Abstract:
    In this paper, we present a technique for the preparation of polymer nanowires with the protein molecule imprinted and binding sites at surface. These surface imprinting nanowires exhibit highly selective recognition for a variety of template proteins, including albumin, hemoglobin, and cytochrome c. This recognition may be through a multistep adsorption, with the specificity conferred by hydrogen bonding and shape selectivity. Due to the protein imprinted sites are located at, or close to, the surface; these imprinted nanowires have a good site accessibility toward the target protein molecules. Furthermore, the large surface area of the nanowires results in large protein molecule binding capacity of the imprinted nanowires.
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