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  • Title: Inversion of chromosome 16 and bone marrow eosinophilia in a myelomonocytic transformation of chronic myeloid leukemia.
    Author: Asou N, Sanada I, Tanaka K, Hidaka M, Suzushima H, Matsuzaki H, Kawano F, Takatsuki K.
    Journal: Cancer Genet Cytogenet; 1992 Jul 15; 61(2):197-200. PubMed ID: 1638503.
    Abstract:
    We report a case of chronic myeloid leukemia (CML) in myelomonocytic transformation associated with bone marrow (BM) eosinophilia. At diagnosis, all BM cells showed a Ph chromosome. At the time of blastic phase, more than 50% of Ph+ cells had a pericentric inversion of chromosome 16, inv(16)(p13q22). This case confirms that blastic transformation of CML can involve any committed progenitor, and myelomonocytic leukemia with BM eosinophilia is specifically associated with rearrangement of chromosome 16 at band p13 and q22.
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