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  • Title: [Insulin allergy: background, diagnosis and treatment].
    Author: Wonders J, Eekhoff EM, Heine R, Bruynzeel DP, Rustemeyer T.
    Journal: Ned Tijdschr Geneeskd; 2005 Dec 10; 149(50):2783-8. PubMed ID: 16385830.
    Abstract:
    An allergic reaction develops in 2.4% of patients that use insulin. This ranges in severity from erythema and pruritus to life-threatening anaphylaxis. llergic reactions to insulin usually occur within a few hours after an injection and are usually due to a local or systemic type I IgE-mediated hypersensitivity reaction. Despite considerable research into the immunogenicity of insulin, this has not yet been clarified completely and allergic reactions to insulin still occur. A systematic diagnostic approach is essential for an adequate treatment plan. A blood test for anti-insulin antibodies and intradermal skin tests are of great importance. There are many options available for the treatment of insulin allergy and each patient must therefore be evaluated individually.
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