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  • Title: Determination of ionization constant (pKa) and octanol-water partition coefficient (Log P) of cyclopiazonic acid.
    Author: Sobolev VS.
    Journal: J AOAC Int; 2005; 88(5):1367-70. PubMed ID: 16385984.
    Abstract:
    The ionization constant (pKa) and the octanol-water partition coefficient (log P) of the important mycotoxin cyclopiazonic acid (CPA) were determined by means of potentiometric titration, and the lipophilicity profile (log D) was calculated. Under the experimental conditions, pKa of CPA = 2.97 +/- 0.09, log P = 3.83 +/- 0.10, and log D at pH 7.4 = -0.58.
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