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Pubmed for Handhelds

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  • Title: Neurological soft signs as predictors of treatment response to selective serotonin reuptake inhibitors in obsessive-compulsive disorder.
    Author: Hollander E, Kaplan A, Schmeidler J, Yang H, Li D, Koran LM, Barbato LM.
    Journal: J Neuropsychiatry Clin Neurosci; 2005; 17(4):472-7. PubMed ID: 16387985.
    Abstract:
    Neurological soft-sign abnormalities have been implicated in obsessive-compulsive disorder (OCD). This first comprehensive data analysis evaluated the association between baseline neurological soft signs and treatment response in 117 OCD patients treated with controlled-release fluvoxamine in a double-blind placebo-controlled trial. Total and right-sided soft signs for the responders and the nonresponders did not differ significantly. Left-sided visuospatial soft signs were significantly increased in treatment nonresponders compared to responders. These subtle neurological abnormalities may implicate a potential subgroup of OCD patients with poorer treatment response. This may have treatment implications and therefore serve as a screening tool in OCD.
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