These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Regulation of CD 38 expression and function by steroid hormones in myometrium.
    Author: Dogan S, Deshpande DA, White TA, Walseth TF, Kannan MS.
    Journal: Mol Cell Endocrinol; 2006 Feb 26; 246(1-2):101-6. PubMed ID: 16388888.
    Abstract:
    CD 38, a 45-kDa transmembrane glycoprotein, is expressed ubiquitously in many cell types, including the myometrial smooth muscle cells. CD 38 is a bifunctional protein, and has both ADP-ribosyl cyclase (cyclase) and cyclic ADP-ribose (cADPR)-hydrolase (hydrolase) activities. The cyclase converts beta-NAD to cADPR, a calcium mobilizing second messenger involved in fertilization, insulin secretion, and muscle contraction. CD 38 expression in smooth muscle is regulated by cytokines, by the steroid hormones estrogen and progesterone, and during gestation in the rat. Estrogen increases CD 38 expression, which is associated with increased cyclase, but not hydrolase, activity, indicating a differential post-translational regulation. Progesterone attenuates estrogen-induced effects on CD 38 expression and activities. This will have implications for increased calcium mobilization and contractility of the myometrium during parturition.
    [Abstract] [Full Text] [Related] [New Search]