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  • Title: Hyperprolinemia is not associated with childhood onset schizophrenia.
    Author: Jacquet H, Rapoport JL, Hecketsweiler B, Bobb A, Thibaut F, Frébourg T, Campion D.
    Journal: Am J Med Genet B Neuropsychiatr Genet; 2006 Mar 05; 141B(2):192. PubMed ID: 16389584.
    Abstract:
    In a previous report [Jacquet et al., 2005] we have shown that mild to moderate hyperprolinemia resulting from several alterations (either a complete deletion or missense mutations) of the proline dehydrogenase (PRODH) gene located on chromosome 22q11 is a risk factor for schizoaffective disorder but not for DSM3 R schizophrenia or bipolar disorder. We now report that hyperprolinemia is not associated with childhood onset schizophrenia (COS).
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