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  • Title: Clinical impact of ganciclovir-resistant cytomegalovirus infections in solid organ transplant patients.
    Author: Boivin G, Goyette N, Gilbert C, Humar A, Covington E.
    Journal: Transpl Infect Dis; 2005; 7(3-4):166-70. PubMed ID: 16390409.
    Abstract:
    Clinical consequences of ganciclovir resistant cytomegalovirus (CMV) infections were studied during 2 large prophylactic trials consisting of 100 days of valganciclovir or ganciclovir prophylaxis in solid organ transplant (SOT) recipients. The first one involved 301 high-risk (CMV donor seropositive/recipient seronegative) SOT recipients excluding lung transplants followed for 12 months, whereas the second one involved 80 lung transplant patients evaluated over 6 months. Among the 7 patients (4 non-lung and 3 lung transplant patients) carrying viruses with known ganciclovir-resistance [corrected] mutations in blood, adverse clinical outcome was only observed in the lung transplant recipients. Additionally, no CMV resistance mutations were observed in non-lung transplant patients receiving valganciclovir.
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