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  • Title: Influence of the electrical stimulation of the hypothalamus on adrenocortical steroidogenesis in hypophysectomized rats.
    Author: Saito H, Sato T, Kaba H, Tadokoro M, Edashige N, Seto K, Kimura F, Kawakami M.
    Journal: Exp Clin Endocrinol; 1992; 99(2):110-2. PubMed ID: 1639117.
    Abstract:
    The electrical stimulation of the ventromedial hypothalamus (VMH), lateral hypothalamic area (LHA), periventricular arcuate nucleus (ARC), and posterior hypothalamus (PHY), on 14C transfer rates from 14C-1-acetate into adrenocortical steroids in adrenal slices of hypophysectomized rats were investigated. The 14C transfer rates into corticosterone and cortisol were increased by the stimulation of the VMH, ARC, and PHY, but decreased by the stimulation of the LHA. From these results, it might be suggested that these hypothalamic structures were involved in the regulation of adrenocortical steroidogenesis without participation of the pituitary.
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