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  • Title: Antimalarial and antiplasmodial activities of norneolignans. Syntheses and SAR.
    Author: Skytte DM, Nielsen SF, Chen M, Zhai L, Olsen CE, Christensen SB.
    Journal: J Med Chem; 2006 Jan 12; 49(1):436-40. PubMed ID: 16392829.
    Abstract:
    A systematic change of the substituents and side chain of the norneolignan hinokiresinol afforded a 10 fold improvement of the IC(50) value toward inhibition of the growth of Plasmodium falciparum. The more potent compounds controlled the parasitemia in mice infected with Plasmodium berghei.
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