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  • Title: Few things in life are "free": cellular uptake of steroid hormones by an active transport mechanism.
    Author: Lin BC, Scanlan TS.
    Journal: Mol Interv; 2005 Dec; 5(6):338-40. PubMed ID: 16394248.
    Abstract:
    Conventional dogma holds that steroid hormones traverse cell membranes passively, owing to their lipophilic nature. The recently characterized protein megalin, however, functions as a transport protein on cell surfaces to carry steroids across the plasma membrane. Upon hydrolysis of steroid-associated binding globulins in lysosomes, free hormone is liberated and may exert its effects in the cell. Megalin-independent mechanisms of steroid uptake are likely important too, as the phenotypes of megalin-deficient mice do not completely mimic the phenotypes of androgen receptor- or estrogen receptor-null mice.
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