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  • Title: [Effect of psychotropic preparations on the activity of Ca- and Mg-dependent ATPase of the sarcoplasmic reticulum].
    Author: Tat'ianenko LV, Lavretskaia ZF, Raĭkhman LM, Moshkovskii IuS, Lebedeva OI.
    Journal: Vopr Med Khim; 1976; 22(3):406-10. PubMed ID: 16400.
    Abstract:
    In sarcoplasmic reticulum of rabbit skeletal muscles the activity of Ca2+, Mg2+- dependent ATPase was distinctly inhibited under effect of neuroleptic drugs - derivatives of phenothiazine and butyrophenone. The effect of tricyclic antidepressants was less pronounced. Tranquilizers (derivatives of 1,4-benzodiazepine) inhibited the enzyme, but trioxazin was only slightly active. High concentrations of lithium salts and of psychostimulants caffeine and corasole were found to stimulate the Ca2+, Mg2+-ATPase activity; low concentrations of the substances slightly inhibited the enzyme. The blocking effect of psychotropic drugs was more distinct, if the enzyme preparations were previously treated with ATP.
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