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  • Title: Clinical variables at age 2 predictive of mental retardation at age 5 in children with pervasive developmental disorder.
    Author: Takeda T, Koyama T, Kanai C, Kurita H.
    Journal: Psychiatry Clin Neurosci; 2005 Dec; 59(6):717-22. PubMed ID: 16401249.
    Abstract:
    This study attempted to find clinical variables evaluated at age 2 that would predict mental retardation (MR, IQ/cognition-adaptation developmental quotient [C-A DQ]<70) at age 5 in 57 children with pervasive developmental disorder (PDD). About two-thirds of subjects had MR at both initial and outcome evaluations. The C-A DQ at initial evaluation was significantly lower in mentally retarded PDD (MRPDD) than in high-functioning (IQ >or= 70) PDD (HFPDD). MRPDD changed less than HFPDD in IQ/C-A DQ between ages 2 and 5. The C-A DQ at age 2 was a potent predictor for MR at age 5 and the total score and three item scores of Childhood Autism Rating Scale-Tokyo Version evaluated at age 2 were also useful in predicting MR at age 5.
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