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  • Title: Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration.
    Author: Whitwell JL, Jack CR, Senjem ML, Josephs KA.
    Journal: Neurology; 2006 Jan 10; 66(1):102-4. PubMed ID: 16401855.
    Abstract:
    The authors used voxel-based morphometry to compare the patterns of brain atrophy in two variants of pathologically confirmed frontotemporal lobar degeneration (FTLD): FTLD with motor neuron disease (FTLD-MND) and FTLD with ubiquitin-only-immunoreactive neuronal changes (FTLD-U). Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more widespread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U.
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