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  • Title: Necrobiotic xanthogranuloma.
    Author: Wee SA, Shupack JL.
    Journal: Dermatol Online J; 2005 Dec 30; 11(4):24. PubMed ID: 16403396.
    Abstract:
    A 67-year-old man presented with a 13-year history of slowly enlarging yellow-red plaques on the face and lower extremity. A biopsy specimen was consistent with necrobiotic xanthogranuloma. Necrobiotic xanthogranuloma is a slowly progressive histiocytic disease that is associated with paraproteinemia in most cases; however, its pathogenesis remains unclear. Although there is no first-line therapy, anecdotal reports have shown variable benefit with chemotherapeutic agents.
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