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  • Title: The characteristics of the nogo-N140 component in somatosensory go/nogo tasks.
    Author: Nakata H, Inui K, Wasaka T, Tamura Y, Kida T, Kakigi R.
    Journal: Neurosci Lett; 2006 Apr 24; 397(3):318-22. PubMed ID: 16406341.
    Abstract:
    Nogo-related brain potentials may not be dependent on sensory modalities but reflect common neural activities specific to the inhibitory process. Recent studies reported that nogo potentials were elicited by not only visual and auditory but also somatosensory stimulation. However, the characteristics of this nogo potential evoked by somatosensory stimulation have been unclear because of the small number of reports. In the present study, therefore, to determine the characteristics of this potential, the effects of stimulus site and response hand were investigated. Electrical stimulation was delivered to the second and fifth digit of one hand, and the subjects had to respond to a go stimulus by pushing a button with the thumb contralateral to the stimulated side as quickly as possible. The amplitudes of the nogo-N140 component (N140 evoked by the nogo stimuli), which is very similar to the nogo-N2 components following visual and auditory stimulation, were unrelated to the stimulated digits, the second and fifth digit of the left and right hand. However, differences between go and nogo ERPs were significantly larger in the hemisphere contralateral to the response hand than the ipsilateral hemisphere. This result was inconsistent with visual and auditory go/nogo studies showing a right-hemisphere dominance or bilateral activities in nogo trials. Therefore, nogo-N140 should be considered to reflect the inhibitory process especially in the hemisphere contralateral to the response hand and the sensory modality dependency of nogo potentials.
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