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  • Title: Current and future peripherally-acting antitussives.
    Author: Dicpinigaitis PV.
    Journal: Respir Physiol Neurobiol; 2006 Jul 28; 152(3):356-62. PubMed ID: 16406742.
    Abstract:
    Cough is among the most common complaints for which medical evaluation is sought. The clinical significance of this problem is evidenced by the enormous financial expenditure on prescription and non-prescription cough remedies worldwide. Centrally-acting antitussive agents, such as opiates, are often associated with undesirable or intolerable side effects, including sedation, nausea, and constipation. Therefore, safe and effective peripherally-acting antitussive agents are particularly desirable. Relatively few commercially-available products suppress cough through a peripheral mechanism of action. Recent research in the field of cough has resulted in the development of several new classes of compounds that may prove to be clinically useful peripherally-acting antitussives.
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