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  • Title: Turning ON the switch--RhoGEFs in plants.
    Author: Shichrur K, Yalovsky S.
    Journal: Trends Plant Sci; 2006 Feb; 11(2):57-9. PubMed ID: 16406756.
    Abstract:
    Plant ROPs (or RACs) are Ras-related, small GTP-binding proteins that function as molecular switches in numerous signaling cascades. ROPs (RACs) cycle between a GDP-bound, inactive state and a GTP-bound, active state. Activation requires guanine-nucleotide exchange factors (GEFs), which were not identified in plants until recently. Alfred Wittinghofer and co-workers' description of a group of plant-specific RhoGEFs opens the way for the elucidation of ROP signaling cascades from membrane receptors to responses.
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