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  • Title: Prognostic indicators in an aggressive pituitary Crooke's cell adenoma.
    Author: Kovacs K, Diep CC, Horvath E, Cusimano M, Smyth H, Lombardero CC, Scheithauer BW, Lloyd RV.
    Journal: Can J Neurol Sci; 2005 Nov; 32(4):540-5. PubMed ID: 16408589.
    Abstract:
    OBJECTIVE: To investigate prognostic indicators in an aggressive Crooke's cell adenoma of the pituitary. METHODS: The surgically removed tumor was studied by histology, immunohistochemistry and transmission electron microscopy. RESULTS: An aggressive invasive sellar tumor removed by repeated surgeries from a 43-year-old woman with pituitary related Cushing's disease was classified as a Crooke's cell adenoma of the pituitary. The application of several cell proliferation markers confirmed the aggressive nature of the tumor. CONCLUSIONS: The investigation of the present case provides additional evidence that pituitary Crooke's cell adenomas may possess aggressive behavior.
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