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  • Title: [Enzyme immunoassay system for the detection of low-avid lgG antibodies to human cytomegalovirus ("CMV-diagnost")].
    Author: Ebralidze LK, Vedunova SL, Mal'tseva NN, Lavrov VF, Gol'tsov VA, Zverev VV.
    Journal: Vopr Virusol; 2005; 50(6):41-4. PubMed ID: 16408631.
    Abstract:
    The new Russian enzyme immunoassay system "CMV-Diagnost" based on the detection of low-avid IgG antibodies has been developed for the rapid diagnosis of cytomegalovirus infection. The system was found not only to determine the strained immunity in response to cytomegalovirus, but also to judge the current infection from the avidity index of detectable IgG antibodies with a high degree of validity. The antibody avidity index of less than 30% suggests an acute stage of primary cytomegalovirus infection. The minimum antibody threshold bodies (deltaOD has been established for the correct interpretation of data on low-avid antibodies. deltaOD of > or =0.6 optic units was for the developed test system "CMV-Diagnost. A correlation was found between the serum levels of low-avid antibodies and IgM antibodies to cytomegalovirus at the acute stage of the disease.
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