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  • Title: [The role of interleukin-5 in manifestation of bronchial hyperreactivity (an experimental study)].
    Author: Sazonov AE, Ivanchuk II, Kapilevich LV, D'iakova EIu, Popova IS, Nosarev AV, Zaĭtseva TN, Tyryshkin AM, Ogorodova LM.
    Journal: Patol Fiziol Eksp Ter; 2005; (4):20-2. PubMed ID: 16408662.
    Abstract:
    Mechanography was used to study contractile reaction of airway smooth muscles in experimental bronchial asthma in intact guinea-pigs and those incubated with IL-5. Development of experimental bronchial asthma (BA) in the animals leads to enhancement of contractile reactions of bronchial smooth muscles in response to histamine action. The exposure to IL-5 of the preparations of bronchial smooth muscles increases histamine-mediated bronchial contractility. This may explain the phenomenon of IL-5-mediated bronchial hyperreactivity in the absence of eosinophilic damage to the tissues. Expression of mRNA of IL-5 receptor alpha-chain suggests that development of IL-5-mediated hypersensitivity of bronchial smooth muscles occurs due to the presence of a relevant IL-5 receptor on their surface.
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