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  • Title: [The relationship between the five beta-fibrinogen gene polymorphisms and cerebral infarction].
    Author: Fu Y, Wei X, Ni PH, Ying YY, Song YY, Chen SD.
    Journal: Zhonghua Nei Ke Za Zhi; 2005 Dec; 44(12):914-7. PubMed ID: 16409729.
    Abstract:
    OBJECTIVE: To investigate the relationship among beta-fibrinogen (Fg) concentration, related gene polymorphisms (including -148C/T, -249C/T, -455G/A, 448G/A, 1689T/G) and cerebral infarction. METHODS: Fg level and its five gene polymorphisms were analyzed with by polymerase chain reaction-restriction fragment length polymorphism in 132 patients with cerebral infarction, 79 patients with other neurological diseases and 92 healthy elders. RESULTS: The plasma Fg level in cerebral infarction patients was significantly higher than that in the patients with other neurological diseases or healthy elders (P < 0.05). In the three groups, the plasma Fg levels in individuals with T-148 and A-455 alleles were higher than those in individuals without T-148 and A-455 alleles (P < 0.05). However, there were no statistically significant differences in the genotype and allele frequencies in the five mutation gene polymorphisms among the three groups (P > 0.05). CONCLUSIONS: Cerebral infarction is a multifactorial disease and an increased Fg level is a risk factor for cerebral infarction. T-148 and A-455 allele can lead to elevated Fg concentration.
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