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  • Title: Immunotherapy with stimulated autologous lymphocytes in a case of a juvenile anaplastic glioma.
    Author: Thomas C, Schober R, Lenard HG, Lumenta CB, Jacques DB, Wechsler W.
    Journal: Neuropediatrics; 1992 Jun; 23(3):123-5. PubMed ID: 1641079.
    Abstract:
    The effect of immunotherapy with stimulated autologous lymphocytes (SAL) in malignant gliomas is documented and discussed in a bioptical and autoptical case study. A five-year-old child with a recurrently operated and radiated right hemispheric anaplastic astrocytoma died six weeks after immunotherapy with mitogen-activated killer cells and recombinant Interleukin-2. The autopsy revealed a large butterfly glioma with partially necrotic gelatinous tissue at the site of the SAL reservoir. The tumor cell density on the right was less than on the left hemisphere, and T-lymphocyte content was higher on the right hemisphere. These results demonstrate a local effect of SAL therapy in vivo, although the tumor progression as a whole could not be stopped. They also demonstrate the need of a detailed neuropathological examination in all cases of immunotherapy of malignant gliomas.
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