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  • Title: Pathobiology of CD30+ cutaneous T-cell lymphomas.
    Author: Kadin ME.
    Journal: J Cutan Pathol; 2006 Feb; 33 Suppl 1():10-7. PubMed ID: 16412208.
    Abstract:
    CD30+ cutaneous lymphoproliferative disorders include lymphomatoid papulosis (LyP) and anaplastic large cell lymphoma (ALCL). LyP is associated with development of lymphoma in nearly 20% of patients. Herein is reviewed the clonal relationship of LyP to malignant lymphoma, the concept of a common stem cell for LyP and associated lymphomas, and the role of genetic instability in lymphomagenesis. The possible role of the CD30+ cell as a regulatory T-cell is introduced and a model for progression of LyP to ALCL is illustrated.
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