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  • Title: [Expression of nestin and neurogenin 3 in the human fetal pancreas].
    Author: Zheng ZM, Chen DM, Li LS, Li JN, Shen L, Lu AL, Wang SL, Bao WH.
    Journal: Zhonghua Wai Ke Za Zhi; 2005 Dec 01; 43(23):1537-40. PubMed ID: 16412293.
    Abstract:
    OBJECTIVE: To examine the expression of nestin and neurogenin 3 (Ngn3), the markers of pancreatic stem cells, in the human fetal pancreas. METHODS: The human fetal pancreas tissue of 12 and 14 weeks were examined for the expression of nestin and Ngn3 using the techniques of immunofluorescence dye and RT-PCR. RESULTS: Both nestin and Ngn3 expressed widely in 12 and 14 weeks before in human fetal pancreatic tissue. In these positive cells there was no co-expressing insulin or glucagon. There were nestin and Ngn3 co-expressing cells in ducts but not in the islets. The results of RT-PCR also indicated the expression of nestin and Ngn3. CONCLUSIONS: There was no expression of the markers of mature endocrine cells in the nestin and Ngn3 positive cells, and they were the marks of no-differentiation cells in the human fetal pancreatic tissue.
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