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  • Title: The AP-1/CJUN signaling cascade is involved in muscle differentiation: implications in muscle wasting during cancer cachexia.
    Author: Moore-Carrasco R, García-Martínez C, Busquets S, Ametller E, Barreiro E, López-Soriano FJ, Argilés JM.
    Journal: FEBS Lett; 2006 Jan 23; 580(2):691-6. PubMed ID: 16412434.
    Abstract:
    The aim of the present study was to investigate a possible role of the AP-1 signaling cascade in the process of wasting associated with cancer cachexia at the level of skeletal muscle. The injection of virus containing the TAM67 protein (a blocker of the AP-1 protein) to the gastrocnemius muscle of tumour-bearing rats resulted in a significant recovery of the muscle mass (which is dramatically reduced as a result of tumour burden), therefore suggesting that AP-1 is certainly involved in the signaling associated with muscle protein accretion. In conclusion, the gene therapy approach presented here clearly suggests an important role for AP-1 in muscle signaling during catabolic states.
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