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  • Title: Ketotifen improves sperm motility and sperm morphology in male patients with leukocytospermia and unexplained infertility.
    Author: Oliva A, Multigner L.
    Journal: Fertil Steril; 2006 Jan; 85(1):240-3. PubMed ID: 16412767.
    Abstract:
    In an open, uncontrolled study, the effect of 12 weeks of daily administration of ketotifen, an antihistamine-like drug with a mast cell stabilizing effect, on the semen quality of 55 men with leukocytospermia and unexplained infertility was examined. After 4 weeks of treatment, white blood cell count dramatically diminished and was accompanied by a significant improvement in sperm motility. A significant increase of morphologically normal sperm cells was observed at 8 weeks of treatment, and these changes remained until at least 4 weeks after the end of treatment.
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