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  • Title: IL-1 can act as number one.
    Author: Gamero AM, Oppenheim JJ.
    Journal: Immunity; 2006 Jan; 24(1):16-7. PubMed ID: 16413919.
    Abstract:
    Both interleukin-1 receptor (IL-1R) and toll-like receptor 2 (TLR2) signal via the adapter molecule MyD88. However, in response to a cutaneous infection challenge, the downstream signaling events diverge and IL-1R, but not TLR2, proves to be essential for host defense.
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