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  • Title: Adverse reactions to dermal fillers: a review of European experiences.
    Author: Andre P, Lowe NJ, Parc A, Clerici TH, Zimmermann U.
    Journal: J Cosmet Laser Ther; 2005 Dec; 7(3-4):171-6. PubMed ID: 16414905.
    Abstract:
    BACKGROUND: In Europe, numerous dermal fillers have been utilized for the past decade. A lot of drawbacks have been reported and sometimes, severe complications occurred. OBJECTIVE: Our purpose is to report the clinical aspects of the adverse reactions following injections of some of the dermal fillers. Histological aspects of complications are also described. RESULTS: Adverse reactions secondary to biodegradable products are usually time limited, but with the non-biodegradable products, we have observed severe, persistent, and recurrent complications. Histological examinations, in cases of non-biodegradable products, may show the presence and persistence of the filler. CONCLUSION: For the moment, there is no ideal dermal filler. All fillers can lead to adverse events and we need to inform patients fully before injecting. Clinical studies with long-term follow-up before launching a new product on the market are recommended. We believe that in Europe, at present, the CE mark is not a guarantee of safety of dermal fillers.
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